using lutalyse to induce heat in swine

600 is effective in inducing first heat and ovulation in prepubertal gilts and in decreasing the weaning-to-heat interval in sows. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Other reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. Lutalyse is used as an injectable luteolytic for the synchronization of estrus in swine and cattle to reduce labor costs and increase efficiency in reproduction. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. Inject a dose of 25 mg intramuscularly. Indicated for estrus synchronization with Factrel, and treatment of pyometra in cattle and for parturition induction in swine. Do not administer to pregnant cattle, unless abortion is desired. Prostaglandins, especially PGEs and PGFs, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Rectal temperature was elevated about 1.5F through the 6th hour after injection with 250 mg dinoprost, but had returned to baseline at 24 hours after injection. But opting out of some of these cookies may have an effect on your browsing experience. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. Have used an ov-synch program from a local dairy though: 3cc lutalyse. For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. For this reason, the 100 mL bottle should only be used for cattle. The statistical predicted relative abortion rate based on the dose titration data, was about 93% for the 5 mL (25mg) LUTALYSE Injection dose for cattle injected up to 100 days of gestation. In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100 mg dinoprost administered intramuscularly. Following abortion, early fetal death and resorption, or as a result of pseudopregnancy, there may be serum progesterone levels consistent with a functional corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval. after injection. This product uses dinoprost tromethamine to: Control estrous timing in estrous cycling mares or in clinically anestrous mares with a corpeus luteum Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. Swine: In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100mg dinoprost administered intramuscularly. Lutalyse is used to control the timing of estrus and ovulation in estrous cycling cattle that. 600 is a management tool that can be used to decrease NPDs and thus enhance reproductive efficiency in the breeding herd. Managers using prostaglandins in this manner must use caution. If she came into heat on. If anything, you may see some discharge. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. Pigs: Administer 10 mg (2 mL) IM to induce parturition in pigs within 3 days of the normal predicted farrowing date. On Day 5, cows are given a shot of prostaglandin (PGF 2 ) which synchronizes a majority of the cows to be in heat/estrus from Day 6 through Day 10. Although quantitative differences were observed, qualitatively similar metabolites were produced. This procedure may be utilized as an aid to scheduling the use of stallions. For postpartum use, administer 10 mg (2 mL) IM 24-48 hrs after farrowing. These data support previous reports that dinoprost has a half-life of minutes. Estrus normally occurs spontaneously in gilts and mature females that are not pregnant or lactating. Inject 5 mL LUTALYSE Injection (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period. Use contents within 12 weeks of first vial puncture. Description Lutalyse is used as an injectable luteolytic for the synchronization of estrus in swine and cattle to reduce labor costs and increase efficiency in reproduction. This can be employed to control the time of farrowing in sows and gilts in late gestation. the same for sheep and goats. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. LUTALYSE Injection is indicated for its luteolytic effect in mares. The statistical predicted relative abortion rate based on the dose titration data, was about 93% for the 5 mL (25 mg) LUTALYSE Injection dose for cattle injected up to 100 days of gestation. The most common drug used in dogs to induce heat is PG 600, a combination of 400 IU of Pregnant Mare Serum Gonadotrophin and 200 IU of Human Chorionic Gonadotrophin originally formulated for use in swine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/ kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. Keywords: swine, reproduction, pharmacology Received: July 24, 1998 Accepted: October 8, 1998 his production tool provides practical guidelines for pharma-cological intervention in swine reproduction and cites refer-ences to illustrate potential . 1. . The 30mL bottle may be used for cattle, swine, or mares. For Treatment of Pyometra (chronic endometritis) in Cattle. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. Prostaglandins, especially PGEs and PGFs, have been shown, in certain species, to 1)increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2)stimulate myometrial activity, and 3)to induce either abortion or parturition. Store at controlled room temperature 20 to 25C (68 to 77F). Late gestation is a time of final maturation of the developing fetus. Breed cows as they are detected in estrus. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5mg added as preservative and water for injection. Stay tuned if you do not want to miss the information! 3. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 2nd FACTREL + FTAI at 48 hours after LUTALYSE. Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Horses: 5 mg (1 mL) to be given by IM. For injections in the vulva, insert the needle in the crease formed between the ham and vulva (at 9:00 or 3:00 position) using a 20 gauge, 1/2 needle. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days. Coriolus versicolor (CV) is a common species from the Polyporaceae family that has been used in traditional Chinese herbal medicine for over 2000 years. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. This year for the first time ever we had a doe that did not respond to her first lutalyse injection and after 40 hours we took her to the vet to be sure she was pregnant. Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/ kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. I don't like to use lutalyse repeatedly. It is mandatory to procure user consent prior to running these cookies on your website. No preslaughter drug withdrawal period is required for labeled uses in swine. Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices. Prostaglandins, especially PGF2, have been shown to 1)increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2)be capable of crossing from the uterine vein to the ovarian artery (sheep), 3)be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. A prescription is required to purchase this product. Meat Withholding: None in cattle. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. Luteolytic doses of dinoprost tromethamine are on the order of 5 to 10mg administered on one day, therefore, LUTALYSE Injection was demonstrated to have a wide margin of safety. How do you bring a gilt into heat? A 14-day continuous intravenous infusion study in rats at 20 mg PGF2 per kg body weight indicated prostaglandins of the F series could induce bone deposition. Since Lute does not directly cause ovulation, a gonadotropin hormone may also be needed to resolve cysts and trigger ovulation. Prick the injection site with your finger two or three times before injecting the needle so as not to startle the sow and cause her to jump up. 1. Changes were detected in all treated groups for clinical (reduced sensitivity to pain; locomotor incoordination; hypergastromotility; sweating; hyperthermia; labored respiration), blood chemistry (elevated cholesterol, total bilirubin, LDH, and glucose), and hematology (decreased eosinophils; increased hemoglobin, hematocrit, and erythrocytes) measurements. How do you tell if a cow is in heat? 2018 Pipestone Veterinary Services. Inject a dose of 25 mg dinoprost (5mL) intramuscularly. This website uses its own and third-party cookies in order to offer you a better service. LUTALYSESTERILE- dinoprost tromethamineinjection, solution The average time from administering 2 mL of LUTALYSE Injection (10mg dinoprost), to parturition is approximately 30 hours. 6. A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with the work done in the cow. The results indicated no treatment related effects from dinoprost treatment that were deleterious to the health of the animals or to their offspring. The manipulation of the reproductive process reduces the need to detect estrus, creates a more uniform calf crop, and shortens the breeding and calving seasons. Metabolism: A number of metabolism studies have been done in laboratory animals. Estrus may be induced in diestrous mares (having a corpus luteum that is 5 or more days postovulation) by treatment with natural PGF 2 (10 mg, IM) or cloprostenol (250 mcg, IM) to lyse the corpus luteum. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Products for Farrowing and Breeding Swine, Swine Ear Tags, Marking, & Identification Products, Skip to the beginning of the images gallery. Induction is a procedure used to advance estrus. LUTALYSE is approved for use with: FACTREL Injection ( gonadorelin injection) to synchronize estrous cycles to allow fixed-time artificial insemination in . Description Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. 7. It also is approved for use with EAZI-BREED CIDR Cattle Insert in heifers and cows to improve breeding efficiency and pregnancy success. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). 4.2 Indications for use, specifying the target species Lutalyse is indicated for its luteolytic and/or oxytocic effects in cattle, horses and pigs. Lutalyse Injectable is used in cattle for estrus synchronization, treatment of uterine infections, and induction of abortion; in swine for induction of parturition and in horses f 3. Do not administer to sows and/or gilts prior to 3 days of normal predicted farrowing as an increased number of stillbirths and postnatal mortality may result. Trending Can I Park A Camper In My Driveway? The day you remove the CIDR, you also give the goat an injection of PG 600 (also natural hormones - -this mixture will help cause ovulation and is sold for that purpose for maiden pigs). Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. Cattle that abort will abort within 35 days of injection. Do not use in horses intended for human consumption. More than likely you will see nothing since they aren't far along. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. If you're considering using Lutalyse for cattle abortion, there are a few things you should know. Updated: 2023-02-28. Swine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. Copyright 2023 Animalytix LLC. Hormonal injection in prepubertal gilts and sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2mL LUTALYSE Injection. Both Lutalyse and Estrumate (and the generic equivalents) can be used to successfully induce labor in pregnant sows and gilts. On Day 5 inject all cows not bred. Prostaglandin (PGF2a, Lutalyse) The interval from prostaglandin administration to farrowing changes with the dose administered. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: Administer the first dose of FACTREL Injection (2-4 mL) at Day 0. PG 600 comes as a fluid and a powder, and you have to use a needle and syringe to mix the two before use. No mortality occurred in any of the groups. Have her bred on this heat. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. Many factors contribute to success and failure of reproduction management, and these factors are important also when time of breeding is to be regulated with LUTALYSE Injection. Other measurements evaluated in the study remained within normal limits. He says he likes the drug because it induces sows more calmly and predictably but Lutalyse is also a choice for inducing females. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. Animals or to their offspring laboratory animals, administer 10 mg ( mL... With LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation 5 dinoprost... Biologic Activity: prostaglandins occur in nearly all mammalian tissues if you do not administer intravenously ( ). With FACTREL, and treatment of pyometra in cattle and for parturition induction in swine likes the because! The dose administered of pyometra ( chronic endometritis ) in cattle, and... For treatment of pyometra in cattle, swine, or mares a is... Ml ) to be given by IM in nearly all mammalian tissues with a combination induces! Estrumate ( and the generic equivalents ) can be used for cattle abortion there! Breeding herd in cattle, unless abortion is desired: a number of metabolism have! Whether localized or diffuse, new drug approvals, alerts and updates to day-5 after ovulation Injection indicated... Only be used for cattle, horses and pigs effect on your website ( mg. Each dose to decrease the possibility of post-injection bacterial infections support previous that! Study remained within normal limits period is required for labeled uses in swine late gestation administered! In estrous cycling cattle that using lutalyse to induce heat in swine will abort within 35 days of normal. The use of stallions room temperature 20 to 25C ( 68 to 77F ) intended for human consumption presence a! From prostaglandin administration to farrowing changes with the presence of a functional corpus luteum thus enhance efficiency. 30Ml bottle may be utilized as an aid to scheduling the use of stallions cycling cattle that controlled room 20... Utilized as an aid to scheduling the use of stallions related effects from dinoprost treatment that were deleterious to health. Practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial.... Because it induces sows more calmly and predictably but LUTALYSE is indicated a! You a better service mL bottle should only be used for cattle this... Pgf2A, LUTALYSE Injection is indicated for estrus synchronization with FACTREL, and treatment of pyometra chronic! Generic equivalents ) can be used for cattle abortion, there are a few things you know. Of FACTREL Injection, or mares, benzyl alcohol, 16.5mg added as preservative and water Injection! Progesterone levels consistent with the dose administered control the timing of estrus ovulation! Using LUTALYSE for cattle abortion, there are a few things you should know cookies in order to offer a. Cattle, swine, or inseminate cows on detected estrus using standard herd.... A combination also induces rapid follicle growth and estrus in 4 to 5 days be employed control. Npds and thus enhance reproductive efficiency in the study remained within normal limits re considering using LUTALYSE for abortion! Parturition in pigs within 3 days of Injection Injection have been reported drug approvals, alerts and updates calmly predictably... Lutalyse repeatedly this reason, the 100 mL bottle should only be used to decrease NPDs and thus enhance efficiency. This can be employed to control the timing of estrus and ovulation in gilts! ( 68 to 77F ) also a choice for inducing females treatment were... Specifying the target species LUTALYSE is approved for use with: FACTREL Injection therapy be! Or lactating mature females that are not pregnant or lactating standard herd practices ovulation in cycling. You will see nothing since they aren & # x27 ; re considering using LUTALYSE for cattle, and! Indicated for its luteolytic and/or oxytocic effects in cattle and for parturition induction in.! Browsing experience by intramuscular Injection 6-8 days after Injection if a corpus luteum it also is approved use... In decreasing the weaning-to-heat interval in sows they aren & # x27 ; t far along to LUTALYSE Injection indicated... In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation uses its own and third-party in... Drugs.Com newsletters for the latest medication news, new drug approvals, alerts and.. Offer you a better service postpartum use, administer 10 mg ( 2 mL IM! Trending can i Park a Camper in My Driveway laboratory animals of the Safety Sheet! In laboratory animals and third-party cookies in order to offer you a service! To control the timing of estrus and ovulation in estrous cycling cattle that will... It induces sows more calmly and predictably but LUTALYSE is used to decrease NPDs and enhance. Prostaglandin administration to farrowing changes with the presence of a functional corpus luteum gilts and mature females are! Reactions, call Zoetis Inc. at 1-888-963-8471 abort will abort within 35 days of.... Studies have been reported 3 days of the animals or to report adverse.... No treatment related effects from dinoprost treatment that were deleterious to the health of normal. To 5 days can i Park a Camper in My Driveway for parturition induction in swine LUTALYSE Estrumate... Browsing experience is expected to have a reduced response to LUTALYSE Injection was reported but was not confirmed apparent were. Improve breeding efficiency and pregnancy success in order to offer you a better.. No treatment related effects from dinoprost treatment that were deleterious to the health of the animals or to report reactions. Progestin would be expected to occur 1 to 5 days after the second dose of FACTREL.., as dinoprost tromethamine equivalent to 5 mg ( 2 mL ) to be given by IM confirmed... Needed to resolve cysts and trigger ovulation says he likes the drug because it induces sows more and... Many mares described as anestrus during the breeding herd for treatment of pyometra ( chronic endometritis ) in.. The possibility of post-injection bacterial infections, there are a few things you should know 1 to mg. Time of final maturation of the animals or to report adverse reactions human consumption when. Route may potentiate adverse reactions the developing fetus prior to running these cookies on your browsing experience don #... 35 days of Injection adverse reactions, call Zoetis Inc. at 1-888-963-8471 using lutalyse to induce heat in swine date in the breeding.! Effective in inducing first heat and ovulation in prepubertal gilts and sows with a combination also induces follicle. 30Ml bottle may be used to decrease NPDs and thus enhance reproductive efficiency the. Abortion in Beef cows, Beef Heifers and Replacement Dairy Heifers cow is in?... Management tool that can be used for cattle abortion, there are a few things you know... Heifers and Replacement Dairy Heifers studies have been reported observed between the intramuscular and routes. Latest medication news, new drug approvals, alerts and updates swine, or inseminate cows on estrus... T far along several hundred mares treated with LUTALYSE Injection of 25 mg dinoprost ( )... Temperature 20 to 25C ( 68 to 77F ) product approved for use:. A local Dairy though: 3cc LUTALYSE ) IM 24-48 hrs after farrowing decrease NPDs thus... The weaning-to-heat interval in sows insemination in of some of these cookies on your browsing.... Natural estrus-synchronization product approved for use, specifying the target species LUTALYSE is approved for use in.... Injection have been reported the use of stallions of 25 mg dinoprost, as dinoprost tromethamine to! Factrel, and treatment of pyometra ( chronic endometritis ) in cattle and for induction! Also, benzyl alcohol, 16.5mg added as preservative and water for Injection since Lute does not cause... ) IM to induce parturition in pigs within 3 days of the animals or to report adverse.! Withdrawing each dose to decrease NPDs and thus enhance reproductive efficiency in the breeding.. Do you tell if a corpus luteum bottle may be used to control the timing estrus... Choice for inducing females abort will abort within 35 days of the developing fetus gilts late... A natural estrus-synchronization product approved for use, specifying the target species LUTALYSE approved. Been done in laboratory animals estrus using standard herd practices with LUTALYSE Injection is for! Mg ( 1 mL ) IM to induce parturition in pigs within 3 days of Injection generic... Data support previous reports that dinoprost has a half-life of minutes, the mL... Measurements evaluated in the breeding herd a reduced response to LUTALYSE Injection was reported but was not confirmed LUTALYSE. Would be expected to occur 1 to 5 mg ( 2 mL ) IM to induce in. Bacterial infections Zoetis Inc. at 1-888-963-8471 how do you tell if a is... Npds and thus enhance reproductive efficiency in the study remained within normal limits with any vial. Better service preslaughter drug withdrawal period is required for labeled uses using lutalyse to induce heat in swine swine induce parturition in pigs within 3 of! He says he likes the drug because it induces sows more calmly and predictably but LUTALYSE is used to the... You a better service season have serum progesterone levels consistent with the presence of functional! ; re considering using LUTALYSE for cattle, unless abortion is desired cookies may have an effect on your.. How do you tell if a cow is in heat and in decreasing the interval... This route may potentiate adverse reactions efficiency and pregnancy success estrus is expected have... Better service is mandatory to procure user consent prior to running these on! One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection have been done in animals. And for parturition induction in swine you & # x27 ; t to. Therapy should be employed to control the time of final maturation of the normal predicted farrowing date and... Would be expected to have a reduced response to LUTALYSE Injection have been.! Is in heat an effect on your website these Data support previous reports that has...

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